This book offers a comprehensive look into the science ofgene expression and regulation. Focusing on topics such asactions of nuclear receptors， RNA processing， and DNAmethylation and imprinting， Gene Expression andRegulation is edited by a leading biologist and includescontributions by experts in the field.
作者簡介
Jun Ma is an Associate Professor at the Division of Developmental Biology， Cincinnati Childrens Hospital Research Foundation and University of Cincinnati College of Medicine. He graduated from Peking University in 1982， majoring in Biology. He did his graduate work with Mark Ptashne at the Department of Biochemistry and Molecular Biology in Harvard University， and was a Junior Fellow at the Harvard Society of Fellows between 1989-1992. He spent the summer of 1988 in the laboratory of Christiane N/isslein-Volhard at the Max-Planck- Institute for Developmental Biology in T/ibingen to collaborate with Wolfgang Driever. He joined the faculty of the University of Cincinnati College of Medicine in 1992 and has remained there since. Currently he also has a collaborative base at the Institute of Biophysics of the Chinese Academy of Sciences in Beijing. His earlier work on the yeast activator GAL4 helped pave the way to the development of the yeast two-hybrid system. His current research focuses on the mechanisms of transcription control and development in Drosophila.
圖書目錄
About the Editor Preface Section Ⅰ The History Chapter 01 Transcription: The Never Ending Story Section Ⅱ The Machinery Chapter 02 The General Transcription Machinery and Preinitiation Complex Formation Chapter 03 The Dynamic Association of RNA Polymerase II with Initiation. Elongation, and RNA Processing Factors during the Transcription Cycle Chapter 04 General Cofactors: TFIID, Mediator and USA Chapter 05 Chromatin and Regulation of Gene Expression Chapter 06 HATs and HDACs 111 Chapter 07 Structure and Function of Core Promoter Elements in RNA Polymerase II Transcription Section Ⅲ The Regulators Chapter 08 Transcriptional Activators and Activation Mechanisms Chapter 09 Transcriptional Repressors and Repression Mechanisms Chapter 10 STATs in Cytokine-mediated Transcriptional Regulation Chapter 11 Transcriptional Regulation by Smads Chapter 12 The Rb and E2F Families of Proteins Chapter 13 c-Jun: A Complex Tale of a Simple Transcription Factor Chapter 14 HIV Tat and the Control of Transcriptional Elongation Chapter 15 Post-translational Modifications of the p53 Transcription Factor Chapter 16 Actions of Nuclear Receptors Chapter 17 NFAT and MEF2, Two Families of Calcium-dependent Transcription Regulators Chapter 18 Hox Genes Chapter 19 Nuclear Factor-kappa B Chapter 20 The ATF Transcription Factors in Cellular Adaptive Responses Section Ⅳ The Genome Chapter 21 Function and Mechanism of Chromatin Boundaries Chapter 22 Heterochromatin and X Inactivation Chapter 23 DNA Methylation Regulates Genomic Imprinting, X Inactivation, and Gene Expression during Mammalian Development Chapter 24 Comparative Genomics of Tissue Specific Gene Expression Chapter 25 Transcription and Genomic Integrity Chapter 26 Cell Death and Transcription Section Ⅴ Special Topics Chapter 27 Pre-mRNA Splicing in Eukaryotic Cells Chapter 28 Genome Organization: The Effects of Transcription-driven DNA Supercoiling on Gene Expression Regulation Chapter 29 The Biogenesis and Function of MicroRNAs Chapter 30 Transcription Factor Dynamics Chapter 31 Actin, Actin-Related Proteins and Actin-Binding Proteins in Transcriptional Control Chapter 32 Wnt Signaling and Transcriptional Regulation Chapter 33 Regulatory Mechanisms for Floral Organ Identity Specification inArabidopsis thaliana Chapter 34 Transcription Control in Bacteria Chapter 35 Gene Therapy: Back to the Basics
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