List of Contributors Foreword Preface I.Cell-based Therapeutics 1.Nano-and Micro-Technology to Spatially and Temporally Control Proteins for Neural Regeneration Anjana Jain and Ravi V Bellamkonda 1.1 Introduction 1.1.1 Response after Injury in CNS and PNS 1.1.2 Nano-and Micro-scale Strategies to Promote Axonal Outgrowth in the CNS and PNS 1.2 Spatially Controlling Proteins 1.2.1 Spatial Control: Permissive Bioactive Hydrogel Scaffolds for Enhanced Regeneration 1.2.2 Spatial Control: Chemical vs.Photochemical Crosslinkers for Immobilization of Bioactive Agents 1.2.3 Other Hydrogel Scaffolds 1.2.4 Spatial Control: Contact.Guidance as a Strategy to Promote Regeneration 1.2.5 Spatial Control: Nerve Guide Conduits Provide an Environment for Axonal Regeneration 1.2.6 Spatial Control: Cell-scaffold Constructs as a Way of Combining Permissive Substrates with Stimuli for Regeneration 1.3 Temporally Controlling the Release of Proteins 1.3.1 Temporal Control: Osmotic Pumps Release Protein to Encourage Axonal Outgrowth 1.3.2 Temporal Control: Slow Release of Trophic Factors Using Microspheres 1.3.3 Temporal Control: Lipid Microtubules for Sustained Release of Stimulatory Trophic Factors 1.3.4 Temporal Control: Demand Driven Release of Trophic Factors 1.4 Conclusion References 2.3-D Fabrication Technology for Tissue Engineering Alice A.Chen, Valerie Liu Tsang, Dirk Albrecht, and Sangeeta N.Bhatia 2.1 Introduction 2.2 Fabrication of Acellular Constructs 2.2.1 Heat-Mediated 3D Fabrication 2.2.2 Light-Mediated Fabrication 2.2.3 Adhesive-Mediated Fabrication 2.2.4 Indirect Fabrication by Molding 2.3 Fabrication of Cellular Constructs 2.4 Fabrication of Hybrid Cell/Scaffold Constructs 2.4.1 Cell-laden Hydrogel Scaffolds by Molding 3.3.4 Extensive Neurite Outgrowth and Active Synapse Formation on PuraMatrix 3.3.5 Compatible with Bioproduction and Clinical Application 3.3.6 Synthetic Origin and Clinical-Grade Quality 3.3.7 Tailor-Made PuraMatrix 3.4 Peptide Surfactants/Detergents Stabilize Membrane Proteins 3.5 Perspective and Remarks Acknowledgements References 4.At the Interface: Advanced Mierofluidic Assays for Study of Cell Function Yoko Kamotani, Dongeun Huh, Nobuyuki Futai, and Shuichi Takayama 4.1 Introduction 4.2 Microfabrication 4.2.1 Soft Lithography …… 5.Multi-phenotypie Cellular Arrays for Biosensing 6.MEMS and Neurosurgery II.Drug Delivery 7.Vascular Zip Codes and Nanoparticle Targeting 8.Engineering Biocompatible Quantum Dots for Ultrasensitive,Real-Time Biological Imaging and Detection 9.Diagnostic and Therapeutic Applications of Metal Nanoshells 10.Nanoporous Microsystems for Islet Cell Replacement 11.Medical Nanotechnology and Pulmonary Pathology 12.Nanodesigned Pore-Containing Systems for Biosensing and Controlled Drug Release 13.Trandermal Drug Delivery using Low-Frequency Sonophoresis 14.Microdevices for Oral Drug Delivery 15.Nanoporous Implants for Controlled Drug Delivery III.Molecular Surface Engineering for the Biological Interface 16.Micro and Nanoscale Smart Polymer Technologies in Biomedicine 17.Supported Lipid Bilayers as Mimics for Cell Surfaces 18.Engineering Cell Adhesion 19.Cell Biology on a Chip About the Editors Index
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