Chapter1 Introduction 1.1 Case Analysis 1.3 Methodology of Clinical Epidemiology 1.4 Roles and Significance of Clinical Epidemiology Chapter 2 Evaluation ofDiagnostic Tests 2.2 Design of a Diagnostic Test 2.4 Important Issues in Study Design of Diagnostic Tests 2.5 Possible Bias in Diagnostic Tests 2.6 Standards for the Reporting of Diagnostic Accuracy Studies 2.7 Case Study on Evaluation of a Diagnostic Test Chapter 3 Evaluation of Etiological Studies 3.1 Case Analysis 3.2 Concept of Etiology in Epidemiology 3.3 Causal Inference 3.4 Major Epidemiological Research Methods in Etiological Evaluation Chapter 4 Clinical Trials 4.2 Introduction to Randomized Controlled Trials 4.3 Essential Elements of a RTC Study 4.4 Limitations of RCTs 4.5 Reporting of Trials and CONSORT Chapter 5 Prognosis 5.1 Clinical Scenario 5.2 Clinical Questions 5.4 Some Concepts 5.5 Research Methods for Prognostic Studies 5.6 Describing Prognosis as a Rate 5.7 Survival Analysis 5.8 Bias in Prognostic Studies and Controlling Methods 5.9 Guidelines for Assessing Evidence about Prognostic Studies Chapter 6 Prevention 6.1 Clinical Scenario 6.2 What is Prevention? Why Prevent？ 6.3 Levels of Prevention 6.4 Screening Test Chapter 7 Clinical Research, Clinical Guidelines and Clinical Practice 7.1 Clinical Scenario 7.2 Randomized ClinicalTrials 7.3 Diagnostic Tests 7.4 Research about Prognosis 7.7 Applying the Evidence to Individual Patients 7.8 Resolution to the Clinical Scenario Chapter 8 Methodological Tools in Clinical Epidemiology 8.2 Sample Size Required for Study 8.3 Resources for Evidence-based Medicine 8.4 0ther BMJ Resources
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