Chapter 1 The Overview of Gene-environment Interaction Section 1 The Fundamental Concepts of Environment I. Environment II. Ecosystem and Ecological Balance III. Human-environmental Interactions Section 2 The Fundammtal Genetic Concepts I. The Genetic Material II. Mutation Section 3 Introduction to Gene-environment Interaction I. Definition of Gene-environment Interaction II. Models of Relationship Between Genotype and Exposure III. Genetic Epidemiology IV. Environmental Genomics V. Gene-environment Interactions and Human Disease Chapter 2 Disease Types: Complex Trait Diseases and Diseases Related to Environment Section 1 Health and Diseases I. Conception of Health II. Conception of Diseases III. Sub-healthy IV. The Impact of Environmental Change on Health and Diseases Section 2 Classification of diseases Based on Molecular, Systems and Organism I. Brief Introduction of Classification of Diseases II. Disease Classification on Molecular, Systems and Organism Levels Section 3 The Overview of the Single Gene Disorder and Complex Disorders I. Inheritance Patterns of Single Gene Disorders II. The Model of Complex Disorder Development III. The Comparison of Single Gene and Complex Disorder Models IV. The Chromosome Structure Variation and Extra-nuclear Inheritance Section 4 Environmental Diseases I. Characteristics of Environmental Diseases II. Kashin-Beck Disease III. Keshan Disease IV. Endimic Fluorosis V. Iodine Deficiency Disorder VI. Endemic Arsenism Chapter 3 The Relationship Between Environmental Exposure, Environmental Response Genes and Disease Phenotypes Section 1 Environment and Phenotype I. Phenotype and Intermediate Phenotype II. Gene, Environment and Disease Phenotype III. Disease Phenotype Section 2 Environmentally Responsive Gene I. Concept of Environmentally Responsive Gene II. Characteristics and Classification of Environmentally Responsive Genes Section 3 Enviromnental Exposures, Environmental Response Genes and Complex Trait Diseases I. Classification of Environmental Exposures II. Environmental Exposure Assessment III. The Relationship Between Environmental Exposure, Environmental Response Genes and Complex Diseases Section 4 Clues of Epidemiology I. Geographical Variation II. Racial Variation III. Short-term Variation IV. Social Economic Variations V. Gender Difference VI. Age Difference VII. Family Variation Chapter 4 Epidemiological Methods for the Gene-environment Interaction Section 1 Basic Epidemiologic Designs I. Cohort Study II. Case-control Study III. Case-only Study IV. Case-crossover Study Section 2 Hybrid Designs I. Nested Case-control Study II. Case-cohort Study Section 3 Family-based Studies I. Case-parent Study II. Case-sibling Study III. Case-offspring Study and Case-spouse Study Chapter 5 Statistic Method of Environment-gene Interaction Section 1 Statistic Method of Environment-gene Interaction I. Linear Regression Analysis II. Multivariate Analysis of Variance (MANOVA) III. Multifactor Dimensionality Reduction (MDR) Section 2 Common High-throughput Omics Analysis Method for Gene-environment Interactions I. Genome-wide Association Analysis of Gene-environment Interactions II. Mendelian Randomization III. Gene Set Enrichment Analysis Section 3 The High-throughput Omics Analysis Software Generally Used in the Interactions of Environment-gene I. SAM II. GSEA III. Cluster & TreeView IV. Bioconductor Chapter 6 The Statistic Model in Environment-gene Interaction Section 1 The Analysis of Environment-gene Interaction I. Concept of Interaction II. The Mathematical Model of Interaction Section 2 Confound
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